3. Bhutagni is related with the Panchmahabhut – five basic elements. The strength of Bhutagni is depends upon the strength of Jathagni. Bhutagni are located in the particles of Mahabhut in the body.

Agni is divided again in four type.
  1. Tikshnagni – excess power
  2. Mrudu Agni – less power
  3. Sama Agni – normal power
  4. Visham Agni – irregular power

Excess Pitta increases the strength of Agni and Agni becomes Tikshna – strong.

Excess Kapha decreases the strength of Agni and Agni becomes Mrudu. – less power.

Excess Vaata creates irregular Agni and Agni becomes Visham – irregular. It means sometimes Agni becomes strong and sometimes becomes poor.

Agni is an important factor for the purpose of treatment.
Agni is responsible for proper metabolism.
Jatharagni digest the food materials, Dhatvagni digest its own Dhatu and divides it in to two part. 
[1] Sara – substantive part 
[2] Kitta – end products. The substantive part produces next Dhatu. 

‘Saam Niram’ is a peculiar and an important result oriented concept in Ayurved and this concept have no correlation with modern chemistry. It is an important factor in a cause of disease and in modification of disease process. This concept is an important and result oriented concept for the treatment in Ayurved.

‘AAM’ originates from improperly digested food materials toxic particles which clog the channels of circulations in the body. [SHROTORODH ] Some of these channels are physical and include the intestines, lymphatic system, arteries and veins, capillaries, and genitourinary tract. Others are nonphysical channels called NADIS through which energy flows. ‘AAM’ toxicity accumulates wherever there is a weakness in the body and will resulted in to disease. 

Normal activity of digestive power [AGNI] is essential for the complete and proper digestion of intake. But due to low digestive power [MANDAGNI] the food is not properly digested, and toxic product is formed is AAM. Therefore its absorption becomes sluggish and it gets retained in the system for a longer time. Due to this retention it becomes fermented or even putrefied. This toxic product remains unabsorbed in the system because of its incomplete digestion and it is the root cause of all diseases.

Tissue metabolism plays an important role in the process of formation of tissues from the nutrient substances (of the particular Dhatu). Hence when the power of the tissue metabolism [DHATVAGNI] of a particular tissue is diminished, either in the liver or in a particular channel, the formation or utilization of that tissue becomes incomplete and AAM is produced. Such tissues containing AAM are called SAAM, - tissues with AAM. This type of pathology is seen in various diseases. In diabetes, fat and muscle tissues are formed as "SAAM TISSUES" because of the low tissue metabolism of the fat and muscle tissues. Hence the normal functional activities of these tissues are hampered. In obesity a similar type of fat tissue is produced due to low tissue metabolism of fat tissue. A peculiar thing observed in these two conditions is that, though there is low tissue metabolism, there is no associated low digestive power; on the contrary digestive power becomes sharper. In all other types of low tissue metabolism there is an associated low digestive power. 

AGNI is the energy responsible for transformation of food substances into body tissues. In the first stage it produces nutritious substance, which is converted to tissues in the second phase of digestion, which is called secondary or tissue digestion. Here the action of tissue metabolism takes place on nutrient food substances, and different tissues are produced. This is the anabolic activity of tissue fire.

The tissues produced by this process are utilized for the liberation of energy required for each and every activity of the body. During this process the tissue substances are again digested, disintegrated, and utilized for the liberation of heat and energy by the tissue metabolism. This is the catabolic process. During this activity of disintegration of tissues certain minute waste products are formed. They are called subtle waste products or KLEDA. Up to a certain limit the existence of these is essential for the body, and the excess is excreted from the body. When this excretion becomes inadequate due to excessive production or its defective excretion, it gets accumulated in the body-which results in the formation of toxic substance – AAM.

Every Dosh has certain qualities, which are antagonistic to the qualities of other Dosh - e.g. the dry and light qualities of Vaata are antagonistic to the oily and heavy qualities of Kapha. Similarly the hot quality of Pitta is antagonistic to the cold quality of Kapha and Vaata. Therefore when two or three Dosh become severely vitiated and combined, they produce interaction between them. In such conditions opposite qualities, instead of nullifying each other interact and produce a toxic substance.

Properties of AAM
  -> It is always in the form of incompletely digested substance.
  -> Hence it is non-homogenous, has a very bad or foul odor which can be experienced only when it is combined with excretory products such as sweat, urine, and feces, or when products such as sputum, vomit, etc., are expelled from the body.
  -> It is very sticky.
  -> It produces lethargy in the body.

Symptoms of AAM
Srotorodhan – Obstruction of circulatory channels - This can occur in any large, small, or minute channel, when it is indicated by stagnation and disturbance in transport, and metabolism can occur even at the cellular level. The commonly observed obstructions are in the liver [affecting the passage of bile], the urinary tract, the fallopian tubes, the blood vessels, the respiratory tract, etc.

Weakness or reduced working power in any part or organ is due to the difficulty produced by AAM in the contraction and relaxation of the musculature of the part, even when the organic structure of the muscle is normal.
Obstruction of the movement of Vaata - AAM on one side causes disturbance in the action of the musculature of the part or organ, and on the other side it causes disturbances in the conduction of nerve impulses, and ultimately the activity of the concerned part becomes reduced or stopped. It will create lack mental clarity and energy and feel weary and unenthusiastic 
Heaviness and Lethargy.
Tongue is coated especially upon awaking in the morning.
Metabolic disturbance Due to various diseases such as obesity, diabetes, etc., metabolic disturbance is produced. 
Signs of AAM

Feeling heavy, muzzy headed, unclear thinking, aches and pains, bloating, gas, skin blemishes, fever, lack of energy, stickiness, foul smells (breath, sweat, urine, stools, phlegm), sinking stool, mucous in stool, turbid urine, lack of appetite or taste, indigestion, sticky/sweet taste in the mouth, copious phlegm. Pulse; deep, dull, slippery, Tongue thick, greasy coating.

Modern signs of Aam: 
High triglycerides, atherosclerosis, late-onset diabetes, high blood sugar levels, some forms of depression, rheumatoid factor, the presence of H. pylori bacteria, leukocytosis or leukocytopenia (deficient and excess white blood cells), excess anti-bodies, Candida albicans in the gut and uterus, blood urea, gout, excess platelet count, excess red blood cells, gall stones as a sign of excess bile, kidney stones as a sign of un-metabolized calcium and oxalates, high liver enzymes (ALT, AST), intra-ocular pressure [glaucoma], bacterial infection, high temperature, tumors. 

Effects of AAM
When such toxins come in contact with Dosh, tissues, or waste product, it produces SAAM DOSH, SAAM DHATU and SAAM MALA. In Ayurvedic texts symptoms of the SAAM and NIRAM stage of the Dosh, tissues, and waste products are described for all the diseases. 

Ayurveda attributes cause of any disease to an imbalance in one or all of the Dosh and for successful treatment of a particular disease physician has to determine, weather the imbalanced Dosh is 'SAAM' or 'NIRAM' .

Thus, according to this concept, Agnimandya is the causes for AAM, this Agnimandya is even not able to digest drugs. Hence, in Saam condition of the patient drugs are unable to give its proper effects and will not be able to cure diseases. After creating Niram status drugs will give miraculous results.